Extra large Advocate provides dogs over 25 kg treatment and prevention of fleas and reduces the incidence of flea allergy dermatitis. Larval flea stages are killed in the surrounding of Advocate treated pets and prevents heartworm infection (Dirofilaria immitis). Advocate also provides treatment and control of roundworms (Toxocara canis, Toxascaris leonina), kills larval, immature and adult worms. It treats and controls hookworms (Ancylostoma caninum, Ancylostoma braziliense, Ancylostoma ceylanicum, Unicinaria stenocephala), whipworm (Trichuris vulpis), generalised demodicosis (Demodex canis), sarcoptic manage (sarcoptes scabiei), ear mites (Otodectes cynotis), and lice (Trichodectes canis, Linognathus setosus).